Treatment Resistant Depression (TRD) Program

Welcome to the Stony Brook Treatment Resistant Depression Program!

Lucian Manu, MDPeople suffering from depression are in extreme pain. And unfortunately, today’s conventional treatments — medications and talk therapy — while effective for some, are not effective for all. This leaves out at least one third of all the individuals suffering from depression.

When this happens, their condition is known as treatment-resistant depression (TRD). It means that the tools an individual has to help don’t match the extent of the challenges and magnitude of the problems the person faces.

New and exciting technologies and treatment solutions such as transcranial magnetic stimulation (TMS), ketamine, electroconvulsive therapy (ECT), vagal nerve stimulation (VNS), and soon, psychedelics, offer hope to these people.  For most, these treatments are lifechanging. For some of them, they are lifesaving.

We established our Stony Brook Treatment Resistant Depression Program as a place where people can receive ta comprehensive assessment and the most advanced treatments for mood disorders. A place where we can learn to use these new treatment modalities together, synergistically, to elevate our expertise in treatment resistant mood disorders to a whole new level.

Our mission is to give people hope by making these new and exciting treatments more available, to more people, sooner.    

To schedule a consultation or make an appointment at our Stony Brook Treatment Resistant Depression Program, call (631) 632-2428.

We’re glad you found us and welcome you to our program.


Lucian Manu, MD
Director, Treatment Resistant Depression Program
Director, Neuromodulation
Stony Brook Medicine




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